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Peptidase 1 (mite) (), also known as endopeptidase 1 (mite), is an enzyme found in various species of mites. This enzyme exhibits cysteine protease activity with broad endopeptidase specificity. The various forms of peptidase 1 pertaining to individual mite species comprise the group 1 mite allergens. Following the naming conventions of allergens, these peptidase 1 variants include Der p 1 of the European house dust mite ''Dermatophagoides pteronyssinus''; Der f 1 of the American house dust mite ''Dermatophagoides farinae'';〔 Eur m 1 of the Mayne's house dust mite ''Euroglyphus maynei'';〔(【引用サイトリンク】url=http://www.uniprot.org/uniprot/P25780 )〕 and Pso o 1 of the sheep scab mite ''Psoroptes ovis''. The group 1 mite allergens, especially Der p 1 and Der f 1, are major sources of house dust mite (HDM) allergies in temperate climates.〔 == History== The first allergen to be purified and characterized was Der p 1, in a 1980 study by Martin D. Chapman and Thomas Platts-Mills.〔 By the end of the decade, it was suspected that Der p 1 was a cysteine protease when its structure showed similarities to that of actinidin and papain. In the mid-1990s, Hewitt ''et al.'', Shakib ''et al.'', and King ''et al.'' proposed methods of Der p 1 promoting allergic responses through its protease activities.〔 In 2002, Pso o 1 was identified and characterized by Lee ''et al.'', who determined its amino acid sequence and found it to be homologous to the other group 1 mite allergens.〔 In 2009, Der f 1 was the first observed instance of a natural allergen in the form of a monomer.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Peptidase 1 (mite)」の詳細全文を読む スポンサード リンク
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